Subsections
[Cr:4, Lc:4, Tt:0, Lb:0]
- Cell membrane Structure and Function: Lipid bilayer and membrane
protein diffusion, principles of transport across the membrane, transporters
and mechanism of active transport, ion channels, ion pumps
and membrane potentials.Examples from both Eukaryotic and Prokaryotic systems.
- Intra-cellular compartments and Membrane trafficking: Overview of the
endomembrane system, molecular mechanism of membrane transport and maintenance
of compartments diversity, types of vesicle transport and their functions,
posttranslational uptake of proteins by peroxisomes, mitochondria and chloroplast,
endocytosis and exocytosis. Prokaryotic cell structure: Cellular compartmentalization,
intracellular structures and their biogenisis
- Mechanisms of Cell signaling: Basic elements of the cell signaling
system, signaling through G-protein-coupled receptors and
intra-cellular mediators, signaling through enzyme coupled cell
surface receptors, intra-cellular receptors and signaling,
convergence, signaling by regulated proteolysis of latent gene
regulatory proteins, divergence and crosstalk among different
signaling pathways, signaling in plants.Cell signalling in prokaryotes.
- The extracellular Matrix and cell interactions: Extracellular matrix
and interaction of cells with extracellular materials, cadherins and
cell-cell adhesion, tight junctions, gap junctions and plasmodesmata,
basal lamina, plant cell wall, integrins and adhesion molecules in
cell signaling. Extracellular layers in prokaryotes.
- Cytoskeleton: Self-assembly and dynamic structure of cytoskeletal
filaments, regulation of cytoskeletal filaments, molecular motors,
cytoskeleton and cell behavior. Bacterial cytoskeleton.
- Cell Division: Molecular basis of cell cycle checkpoints, regulation
of cell division and cell growth, causes and genetics of cancer.
- B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts and P. Walter,
Molecular Biology of the Cell, 5th Edn., Garland Science
(2008).
- G. Karp, Cell Biology, 6th Edn., John Wiley and Sons
Inc.(2010).
- H. Lodish, A. Berk, C. A. Kaiser, M. Krieger, M. P. Scott, A.
Bretscher, H. Ploegh and P. Matsudaira, Molecular Cell Biology
6th Edn., W. H. Freeman (2007).
