Dr. Vidya Devi Negi |
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vidya(AT)iisermohali.ac.in | ||
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Research Area Infection biology and host-pathogen interaction |
Research Focus The research interest of 2i-Lab The lab is interested in exploring the Salmonella infection mediated pathogenies and associated immunological outcomes. Salmonella enterica serovar Typhimurium is a Gram-negative bacterium that infects many hosts, including amoeba, invertebrates, humans, and plants. S. Typhi is a human-specific serovar causing typhoid fever. Bacterial evolution and the associated consequences Also, I am interested in looking for the impact of Salmonella infection on obesity/diabetes and how bacterial infection can increase obesity and diabetes incidences using the worm Caenorhabditis elegans (C. elegans) model. Obesity and diabetes further increase the risk of various infections like Streptococcus infection etc., among the patient. Few reports describe the contrasting scenarios where microbe can lead to host obesity, especially viruses and the altered gut microbiota giving rise to the new field of infectobesity. The C. elegans is a well-established model system used for host-pathogen interaction, including Salmonella, Pseudomonas, immune response and immune signalling, obesity and diabetes. This global obesity and diabetes scenario led me to think about Salmonella infection mediated obesity and its association with diabetes using C. elegans as a model. Infection mediated developmental defects using the C. elegans model Also, the current work going on in the lab is about studying the developmental defects due to Salmonella infection by using C. elegans as a model system. What severity of the defect Salmonella can cause, as this pathogen is known to infect pregnant women and neonates and lead to preterm birth or even foetal loss. We found that infection has a significant impact on the development of the worm in terms of egg morphology, hatching behaviour, different larval stage development, and even adulthood and gonadogenesis. We are looking out the mechanism of how Salmonella infection can cause these defects. Salmonella infection is also able to cause the Dauer formation in the worm. We have found that the Salmonella infection can cause the dauer formation in C. elegans, and the phenotype persists up to the 5th generation. Still, beyond that, the worm has adopted itself to eat the Salmonella as their regular food, and no more are responding against the pathogens.
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Selected Publications
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