Dr. S. S. V. Rama Sastry
Professor , Chemical Sciences

Email ramsastry(AT)iisermohali.ac.in
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ORCID ID 0000-0001-5814-9092
Research Area
Organic Synthesis and Catalysis
Research Focus

Our research primarily centres on the following areas:

(i) Organocatalysis with phosphines​​: We routinely pursue metal-free chemistry with nucleophilic trivalent organophosphines. Some key contributions to this area include the development of asymmetric intramolecular Morita-Baylis-Hillman reaction and its variants, phosphine-promoted reductive and vinylogous aldol reactions, phosphine-catalyzed intramolecular hydroalkylation, and hydroacylation chemistry, etc.

(ii) Cascade transformation with sulphur slides: Sulfur ylides are traditionally employed to synthesize cyclopropanes, epoxides, and aziridines from the respective olefins, carbonyls, and imines. We articulated several one-pot cascade transformations employing sulfur ylides as reagents that provided facile access to unprecedented cyclopropanoids. We have manipulated the complexity of the molecular scaffolds by the rational design of the substrates.

Selected Publications

Click Here for the complete list of publications

  • Dutta, L.; Mondal, A.; Maurya, J. P.; Mukhopadhyay, D.; Ramasastry, S. S. V. Chem. Comm. 2023, 59, 11045-11056 [Invited feature article on 'organocatalysis using phosphines']
  • Singh, B.;# Ansari, A. J.;# Malik, N.; Ramasastry, S. S. V. Chem. Sci. 2023, 14, 6963-6969 [#Contributed equally]
  • Dutta, L.; Ramasastry, S. S. V. Org. Lett. 2022, 24, 7665-7670
  • Singh, B.; Bankar, S. K.; Ramasastry, S. S. V. Org. Lett. 2022, 24, 1043-1048.
  • Kumar, P.; Kumar, P; Venkataramani, S.; Ramasastry, S. S. V. ACS Catal. 2022, 12, 963-970.
  • Mondal, A.; Satpathi, B.; Ramasastry, S. S. V. Org. Lett. 2022, 24, 256-261.
  • Mondal, A.; Shivangi.; Tung, P.; Wagulde, S.; Ramasastry, S. S. V. Chem. Comm. 2021, 57, 9260-9263.
  • Kumar, P.;# Shirke, R. P.;# Yadav, S.; Ramasastry, S. S. V. Org. Lett. 2021, 23, 4909-4914 [#Contributed equally to the work]
  • Yadav, S.; Ramasastry, S. S. V. Chem. Comm. 2021, 57, 77-80.
  • Mishra, U. K.;# Patel, K.;# Ramasastry, S. S. V. Org. Lett. 2020, 22, 3815 [#These authors contributed equally to this work]
  • Singh, B.;# Bankar, S. K.;# Kumar, K.; Ramasastry, S. S. V. Chem. Sci. 2020, 11, 4948 [#These authors contributed equally to this work]
  • Satpathi, B.; Wagulde, S. V.; Ramasastry, S. S. V. Chem. Comm. 2017, DOI: 10.1039/C7CC02524F.
  • Mishra, U. K.; Yadav, S.; Ramasastry, S. S. V. J. Org. Chem. 2017, DOI: 10.1021/acs.joc.7b00865.
  • Raghu, M.;‡ Grover, J.;‡ Ramasastry, S. S. V. Chem. Eur. J. 2016, 22, 18316. [Invited for a ‘Frontispiece’] [‡These authors contributed equally to this work]
  • Satpathi, B.; Ramasastry, S. S. V. Synlett 2016, 27, 2178. [Invited 'Synpacts' article]
  • Bankar, S. K.; Mathew, J.; Ramasastry, S. S. V. Chem. Commun. 2016, 52, 5569. [Highlighted in 'Synfacts', See: Snieckus, V.; Gomes, S. Synfacts 2016, 12, 0563]
  • Dhiman, S.; Mishra, U. K.; Ramasastry, S. S. V. Angew. Chem. Intl. Ed. 2016, 55, 7737.
  • Shirke, R. P.;† Reddy, V.;† Anand, R. V.; Ramasastry, S. S. V. Synthesis 2016, 48, 1865. [Invited article towards the special issue ‘Cyclization Tactics and Strategies’] [†These authors contributed equally to this work]
  • Manisha.; Dhiman, S.; Mathew, J.; Ramasastry, S. S. V. Org. Biomol. Chem. 2016, 14, 5563. [Invited article towards the thematic issue 'New Talent’]
  • Satpathi, B,; Ramasastry, S. S. V. Angew. Chem. Intl. Ed. 2016, 55, 1777.