Abstract: Unrepaired DNA damage leads to genomic instability and is one of the hallmarks of all cancer forms. While many DNA repair pathways and mechanisms have been discovered in the last two decades, the crosstalk and redundancies among these pathways remain a challenge in designing efficient cancer therapies. Additionally, DNA:RNA:DNA trinucleotide structures, called R-loops, are emerging as new biomarkers for many cancers and neurodegenerative diseases. While R-loops accumulation leads to DNA breaks and genome instability, they also play a role in the repair of certain DNA breaks. My work has identified novel R-loop regulating factors and pathways in cancer cells, and their association with genome stability. It is significant as understanding how R-loops and DNA repair pathways cross-talk will further help us to identify and design better therapeutic strategies.

Meeting ID: 998 0712 3118
Passcode: 990453