BIO404: Cellular and molecular basis of the immune response

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Basic concepts in immunology: Hematopoiesis. Cells of immune system. Basic concepts of Innate and Adaptive immunity.(A small introduction to plant immunity). Plant immunity portion majorly can be discussed in plant physiology course.
Innate Immunity: Pattern recognition. Complement system. Induced innate responses to infection.
Antigen recognition by B-cell and T-cell receptors.
Generation of lymphocyte antigen receptors: Immunoglobulin gene rearrangement. T-cell receptor gene rearrangement.
Antigen presentation to T-cells: MHC complex: structure and function.
Signaling through immune receptors: Immunological synapse. General principles of signal transduction through T-cell receptor activation. Costimulation. Cytokine receptors.
Development and survival of lymphocytes: B-cell development. T-cell development. Positive and negative selection of T-cells. Survival and maturation of lymphocytes in peripheral lymphoid tissues.
T-cell-mediated immunity.
Humoral immunity.
Dynamics of adaptive immunity: Immunological memory. Mucosal immunity.
Immune system in health and disease: Failures of host immunity. Immunodeficiency. Allergy and hypersensitivity. Autoimmunity.
Evolution of immune system.
Techniques in immunology: ELISA. RIA. Immunofluorescence and immunohistochemistry. Immunoprecipitation. Immunoblotting. Flow cytometry. Elispot. Monoclonal antibody and Hybridoma technology. Isolation and characterization of lymphocytes.