Subsections
[Cr:4, Lc:4, Tt:0, Lb:0]
- Introduction: What is developmental biology? History and Basic
Concepts
- From Sperm and Egg to Embryo: 1. Beginning the Developmental Program:
Gametogenesis, Structure of eggs and sperm, Comparing oogenesis and
spermatogenesis 2. Fertilization: Beginning a New Organism- Gamete
recognition, Gamete fusion and prevention of polyspermy, Activation of
egg metabolism, Fusion of the genetic material
- Early Embryogenesis: Cleavage: Generating a Multicellular Embryo (a)
Overview of Cleavage Amphibians/Birds/Mammals, Gastrulation and cell
movement and types of movement, Sea urchin/Chick/Amphibia, Germ layers
(b) Cellular basis of morphogenesis, cell motility and the molecular
players
- Body Patterning: Animal-Vegetal Axis, Rotation of Fertilization and
the Dorso-Ventral Axis Organizer in Amphibia, Development of Body plan
in Drosophila, Maternal genes, Zygotic genes, Segment Identity genes.
Segment identity and Hox genes.
- Differential gene expression during development: Genomic Constancy
during Cell Differentiation, Differential Gene Activity Regulation of
Gene Expression in Early Development Transition from maternal to
zygotic control. Models of Cell Differentiation Introduction to
developmental genetics (techniques and concepts)
- Completing the Life Cycle, and New Beginnings— Sex determination,
Dosage compensation, Imprinting Introduction to concepts in stem cell
biology (renewal, potency, etc.)
- Development and Evolution: Developmental mechanisms of evolutionary
change Evolution of morphological novelty
- S. F. Gilbert, Developmental Biology, 8th Edn., Sinauer
Associates Inc. (2006).
- L. Wolpert, J. Smith, T. Jessell, P. Lawrence, E. Robertson and E.
Meyerowitz, Principles of Development, 3rd Edn., Oxford Univ
Press (2006).
