Subsections
[Cr:4, Lc:3, Tt:1, Lb:0]
This course intends to give an introduction to information storage and processing by
biological macromolecules (DNA and protein sequences) and biochemical pathways in
cellular processes. This is an interdisciplinary area in modern biology evolving through
the past two decades with inputs from mathematics, statistics, physical sciences, computer
science and several other engineering sciences, to understand how biological systems work.
- History of the rise of Bioinformatics and Computational Biology.
- Basic information theory.
- Cell as an information-processing system.
- DNA and Proteins as informational molecules.
- Computation in network of genes, protein structure, protein-protein interactions.
- Biochemical pathways and cellular processes: Models of regulation.
- Basics of metabolic control analysis.
- Network analysis of biochemical pathways.
- Introduction to some biological repositories of information.
- J. Ramsden, Bioinformatics: An Introduction (Computational Biology). Springer (2015).
- A. Lesk, Introduction to Bioinformatics. Oxford University Press (2015).
- J. M. Bower, Hamid Bolouri, Computational Modeling of Genetic and Biochemical
Networks, Ane Books (2004).
- J. Collado-Vides and R. Hofestädt, Gene Regulation and Metabolism, MIT Press
(2004).
