Subsections
[Cr:4, Lc:3, Tt:1, Lb:0]
- Introduction: Genetics vs. Epigenetics
- Trans-generational epigenetic and non-genetic inheritance, epigenetic epidemiology
- Review of genome composition: Coding/noncoding DNA, foreign DNA, regulatory elements.
- Nucleosomes and hierarchical chromatin packing.
- Molecular mechanisms of epigenetic regulation: DNA methylation, histone modifications,
ATP-dependent chromatin remodelling, evolution of epigenetic mechanisms.
- Principal Chromatin Types and their maintenance
- Role of non-coding RNAs in epigenetic regulation
- Higher order spatial conformation of chromatin and 3D genome architecture
- Sub-nuclear compartments and phase separation
- Mono-allelic expression, dosage compensation and genomic imprinting
- Epigenetic reprogramming during germline/embryonic development and tissue regeneration
- Epigenetic control of DNA replication and repair.
- Epigenetic dysregulation during disease conditions.
- Experimental and computational technologies to study the epigenome.
- Journal club on landmark articles
- Epigenetics by C David Allis, Marie-Laure Caparros, and others (Text book)
- Epigenetics by Lyly Armstrong (Text book)
- Evolution in Four Dimensions. By Eva Jablonka and Marion J. Lamb (Popular science)
