Subsections
[Cr:4, Lc:4, Tt:0, Lb:0]
- Fundamentals of Nanotechnology in Drug Delivery Nanotechnology in Drug Delivery: Past, Present and Future; Conventional delivery of pharmaceuticals and its limitations; Significance of nano-size in Pharmacy, biotechnology and medicine; Physicochemical Principles of nano-sized Drug Delivery Systems; Biopharmaceutical, Physiological, and Clinical Considerations for Nanotechnology in Drug Delivery
- Pharmacokinetics and Bio distribution Introduction: Definitions, concepts of Absorption, Distribution, Metabolism and excretion, concentration time profile, Bioavailability, bio pharmaceutics and pharmacokinetics in drug research. Biotransformation of drugs: Drug metabolizing enzymes, chemical pathways of Drug transformation, Phase-I and Phase-II reactions, Factors affecting drug transformation Prodrugs: Application of produg design, enhancement of bioavailability and duration of action, limitations. Bioavailability and Bioequivalence: measurement of bioavailability, Plasma level-time studies, intro-in vivo correlations
- Nano carriers for Drug Delivery: Design, fabrication Properties and applications Closed bilayered system: Introduction, structural aspects, preparation, characterization, evaluation and applications of liposomes, niosomes, erythrosomes etc. Polymeric Nanoparticles: Introduction, preparation, characterization, evaluation and pharmaceutical applications. Nano-emulsions and polymeric micelles drug vehicles: Introduction, composition of the multiple emulsion and stability, Miscellaneous- Organic inorganic hybrid nanoparticles, Solid Lipid Nanoparticles, Self-emulsifying drug delivery systems (SEDDS). Mode of application of Nano carriers- Oral, Parenteral, Pulmonary, Nasal, Transdermal, Ocular, dental etc.
- Controlled and Targeted drug delivery
Programmed Drug Delivery Systems- principles of sustained, controlled, pulsatile and triggered release of drug from nanoparticles. Concept of targeting- Targeting Approaches, Transport Across Biological Barriers, mechanisms of drug targeting, Ideal carrier system and approach Disease-Related Approaches by Nanotherapeutics- nanoparticles for Cancer, Skin Diseases, Bacterial, Diseases, Parasites Diseases and Inflammatory Disease.
- Nano toxicology and regulatory issues- Potential Risks and Remedies Human health and safety- Interaction of nanomaterials with biological systems, Toxicology of nanoparticles- in-vitro and in-vivo, Complications with Nanotoxicity studies, environmental impact of nano-materials, Regulatory Toxicology. Bio-imaging tools Overview of tools and tasks in various biological and biomedical imaging modalities, such as fluorescence microscopy and electron microscopy (SEM, TEM).
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- Alexander T. Florence; David Attwood, Physicochemical Principles of Pharmacy Pharmaceutical Press, 2011
- Milo Gibaldi and Donald Perrier, Pharmacokinetics, Second Edition, Informa publisher 2006
- Ram B. Gupta, Uday B. Kompella, Nanoparticle technology for Drug delivery,Taylor & Francis publisher, 2006
- M. A. Mateescu P. Ispas-Szabo E. Assaad, Controlled Drug Delivery, Woodhead Publishing , 2014
- Padma Devarajan, Sanyog Jain, Targeted Drug Delivery : Concepts and Design, Springer publisher, 2015
- Philippe Houdy, Marcel Lahmani, Francelyne Marano, Nanoethics and Nanotoxicology, Springer-Verlag Publisher 2011
- P. Michael Conn, Essential Bioimaging Methods, Academic Press, 2009
