Subsections
[Cr:4, Lc:3, Tt:0, Lb:0]
Knowledge of the content of CHM306 is essential to follow this course.
- Metal ions in biology; Active-site structure and function of metallo-proteins and enzymes with Mg, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Mo and W ions.
- Heme and Nonheme systems with mono-, di- and multinuclear metal centers, such as Fe: Hb, Mb, Hr, P-450, MMO, ferridoxins, Fe-S clusters; Cu: hemocyanin, hemerythrin; Mn: SOD, Catalase; Co: vitamin B12; Zn: CPA, CA; Ni: urease. Metal environments (ligand type, coordination, geometry), electronic, magnetic and redox properties.
- Some biological processes, such as electron transfer, oxygen-binding, reduction of oxygen to peroxide and superoxide species; their utilization in hydroxylation and epoxidation.
- Further discussions on Nitrogenase and Oxygen Evolving Center in Photosystem II.
- S. J. Lippard, J. M. Berg, Principles of Bioinorganic Chemistry. 1st Ed, University Science Books, California, 1994.
- H. B. Gray, E. I. Stiefel, J. S. Valentine, I. Bertini, Biological Inorganic Chemistry: Structure and Reactivity, 1st Ed, University Science Books, California, 2006.
- L. Que (Editor), Physical Methods in Bioinorganic Chemistry: Spectroscopy and Magnetism, 1st Ed, University Science Books, California, 2000.
- R. H. Holm, E. I. Solomon (Guest Editors), Chemical Review, 1996, 96(7), 2237-3031. Special Issue on Bioinorganic Enzymology.
- R. H. Holm, E. I. Solomon (Guest Editors), Chemical Review, 2004, 104(2), 347-1200. Special issue on Biomimetic Inorgnaic Chemistry.
