Subsections
[Cr:4, Lc:3, Tt:0, Lb:0]
- In this course we would take a practical approach to understanding a variety of tools used in genetic analysis. A special feature of this course would also be to address how Genome-wide tools and Next generation sequencing technologies are impacting the practice of genetics.
- The course would cover bacterial genetics , phage genetics and yeast genetics through classical and reverse genetics approaches; human genetic mapping through next generation sequencing. Other topics would include, Selex, in vitro genetics, directed evolution, genome editing and the CRISPR Cas toolbox, manipulation of genomes and synthetic genomics.
- The course would be taught by discussing and analyzing published papers, and also will be supplemented with a few lectures.
- Mardis E. R. (2008) The impact of next-generation sequencing
technology on genetics. Trends in Genetics, 24, 133-141, 2008.
- MacLean D., Jones J. D. G., and Studholme D. J. (2009) Application of
next-generation sequencing technologies to microbial genetics, Nature
Reviews in Microbiology. 287-296, 2009
- Shendure J. (2011), Next Generation Human genetics. Genome Biology 12,
408, 2011.
- Doudna, JA (2020), The promise and challenge of therapeutic genome editing. Nature volume 578, pages229–236(2020).
- Wang L, Jiang S, Chen C, He W, Wu X, Wang F, Tong T, Zou X, Li Z, Luo J, Deng Z, Chen S (2018). Synthetic Genomics: From DNA Synthesis to Genome Design Angew Chem Int Ed Engl. 57:1748-1756.
- A. J. F. Griffiths, S. R. Wessler, R. C. Lewontin and S. B. Carroll,
Introduction to Genetic Analysis, 9th Edn., W. H. Freeman
(2007).
