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The cancer cell biology course objective will be achieved through brief overview of biology of a cancer cell and through the in-depth discussion of two research papers each week. Initially, there will be lectures given on topics (mentioned below) which will be followed by extensive discussion of research articles that will be primarily driven by the course participants. The students will practice critical reading and discussion of scientific papers and learn to evaluate data and methodologies.
- History of Cancer.
- Brief overview of Cell cycle control and Genome stability.
- Genetic Pathways in Cancer: Tumor Suppresor, Oncogenes, Proto-oncogenes and their cellular functions.
- Cancer Stem cells.
- Metastasis and Angiogenesis.
- Cancer immunology.
- Future of Cancer Research.
- Siddhartha Mukherjee, The Emperor of All Maladies: A Biography of Cancer
- Bruce Alberts, Molecular Biology of the Cell, Fifth edition
- Vogelstein, B., E. R. Fearon, S. R. Hamilton, S. E. Kern, A. C. Preisinger, M. Leppert, Y. Nakamura,
R. White, A. M. Smits & J. L. Bos., Genetic alterations during colorectal-tumor development, N Engl
J Med. 319 (1988): 525-532.
- Goodrich, D. W., N. P. Wang, Y. W. Qian, E. Lee & W. H. Lee., The retinoblastoma gene product
regulates progression through the G1 phase of the cell cycle, Cell 67 (1991): 293-302.
- Artandi, S. E., S. Chang, S. L. Lee, S. Alson, G. J. Gottlieb, L. Chin & R. A. DePinho., Telomere dysfunction promotes non-reciprocal translocations and epithelial cancer in mice, Nature 406 (2000):641-645.
- Al-Hajj, M., M. S. Wicha, A. Benito-Hernandez, S. J. Morrison & M. F Clarke. Prospective identification of tumorigenic breast cancer cells, Proc. Natl Acad. Sci. USA 100 (2003): 3983-3988.
- Clark, E. A., T. R. Golub, E. S. Lander & R. O. Hynes., Genomic analysis of metastasis reveals an essential role for RhoC, Nature 406 (2000): 532-535.
- Paez, J. G., P. A. Janne, J. C. Lee, S. Tracy, H. Greulich, S. Gabriel, P. Herman, F. J. Kaye, N. Lindeman, T. J. Boggon, K. Naoki, H. Sasaki, Y. Fujii, M. J. Eck, W. R. Sellers, B. E. Johnson & M. Meyerson., EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy, Science 304 (2004): 1497-1500.
